The present invention relates to hematopoietic stem cells and to methods of treating diseases and disorders, including genetic diseases and disorders and infectious diseases, using same. The invention additionally relates to methods of identifying agents that promote growth, engraftment or differentiation of stem cells.

A invenção atual relaciona-se às pilhas de haste hematopoietic e aos métodos de tratar doenças e disorders, including doenças e disorders genetic e doenças infectious, usando mesmos. A invenção relaciona-se adicionalmente aos métodos de identificar os agentes que promovem o crescimento, o engraftment ou o differentiation de pilhas de haste.