A process for the preparation of
5-(3,5-dimethylphenoxymethyl)-2-oxazolidinone, which includes:
a) reacting 3,5-dimethylphonel with epichlorohydrin to obtain a mixture of
1-(3,5-dimethylphenoxy)2,3-epoxy propane (1) and
1-(3,5-dimethylphenoxy)-3-chloro-2-propanol (2);
b) reacting the mixture of (1) and (2) obtained from step (a) with
benzylamine to obtain a first compound;
c) reducing the first compound with hydrogen in presence of ammonia, to
obtain a second compound; and
d) reacting the second compound with dimethylcarbonate in the presence of a
strong base to obtain 5-(3,5-dimethlphenoxymethyl)-2-oxazolidinone.
Um processo para a preparação de 5-(3,5-dimethylphenoxymethyl)-2-oxazolidinone, que inclui: a) reagindo 3,5-dimethylphonel com o epichlorohydrin para obter uma mistura 1-(3,5-dimethylphenoxy)2,3-epoxy do propane (1) e do 1-(3,5-dimethylphenoxy)-3-chloro-2-propanol (2); b) reagindo a mistura de (1) e de (2) obtido da etapa (a) com o benzylamine para obter um primeiro composto; c) reduzindo o primeiro composto com hidrogênio na presença da amônia, para obter um segundo composto; e d) reagindo o segundo composto com o dimethylcarbonate na presença de uma base forte para obter 5-(3,5-dimethlphenoxymethyl)-2-oxazolidinone.