A process for the preparation of 5-(3,5-dimethylphenoxymethyl)-2-oxazolidinone, which includes: a) reacting 3,5-dimethylphonel with epichlorohydrin to obtain a mixture of 1-(3,5-dimethylphenoxy)2,3-epoxy propane (1) and 1-(3,5-dimethylphenoxy)-3-chloro-2-propanol (2); b) reacting the mixture of (1) and (2) obtained from step (a) with benzylamine to obtain a first compound; c) reducing the first compound with hydrogen in presence of ammonia, to obtain a second compound; and d) reacting the second compound with dimethylcarbonate in the presence of a strong base to obtain 5-(3,5-dimethlphenoxymethyl)-2-oxazolidinone.

Um processo para a preparação de 5-(3,5-dimethylphenoxymethyl)-2-oxazolidinone, que inclui: a) reagindo 3,5-dimethylphonel com o epichlorohydrin para obter uma mistura 1-(3,5-dimethylphenoxy)2,3-epoxy do propane (1) e do 1-(3,5-dimethylphenoxy)-3-chloro-2-propanol (2); b) reagindo a mistura de (1) e de (2) obtido da etapa (a) com o benzylamine para obter um primeiro composto; c) reduzindo o primeiro composto com hidrogênio na presença da amônia, para obter um segundo composto; e d) reagindo o segundo composto com o dimethylcarbonate na presença de uma base forte para obter 5-(3,5-dimethlphenoxymethyl)-2-oxazolidinone.

 
Web www.patentalert.com

< Use of (+)-tramadol, O-demethyltramadol or (+)-O-demethyl-tramadol, O-desmethyl-N-mono-desmethyl-tramadol or (+)- O-desmethyl-N-mono-desmethyltramadol

< Process for the preparation of 1-benzyl-4(5,6-dimethoxy-1-indanon)-2-yl) methyl piperidine hydrochloride (Donepezil HCL)

> Enzyme inhibitors for metabolic redirection

> Method for preparing microparticles having a selected polymer molecular weight

~ 00065