A method is described for improving the pharmacokinetics of a drug in a subject, by co-administering oligomers, preferably PMO's (phosphorodiamidate morpholino oligonucleotides), antisense to RNAs encoding drug-metabolizing enzymes, particularly p450 enzymes. The oligomers reduce production of the drug-metabolizing enzymes, which extends drug half-life and effectiveness and/or decreases drug toxicity.

Un método es descrito para mejorar los pharmacokinetics de una droga en un tema, por los oligomers co-que administran, preferiblemente PMO (oligonucleotides) del morpholino del phosphorodiamidate, antisense a las enzimas de droga-metabolizacio'n de codificación de RNAs, particularmente enzimas p450. Los oligomers reducen la producción de las enzimas de droga-metabolizacio'n, que amplía período y eficacia de la droga y/o disminuye toxicidad de la droga.

 
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