A mammal lacking expression of particular CD45 isoform in certain cells of the immune system is provided. The mammal may optionally contain a transgene encoding the CD45RO isoform. Also provided are methods of using these mammals.

Une expression manquante mammifère de l'isoform CD45 particulier en certaines cellules du système immunitaire est fournie. Le mammifère peut sur option contenir un transgene codant l'isoform de CD45RO. En outre fournies sont des méthodes d'employer ces mammifères.
 
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