The present invention relates to pyrimidine-2,4,6-trione metalloproteinase inhibitors of the formula ##STR1## wherein X, Y, Ar.sup.1, Z, R.sup.1, R.sup.2 and R.sup.3 are as defined in the specification, and to pharmaceutical compositions and methods of treating inflammation, cancer and other disorders.

De onderhavige uitvinding heeft op pyrimidine-2.4.6-trione metalloproteinase inhibitors van de formule ## STR1 ## betrekking waarin X, Y, Ar.sup.1, Z, R.sup.1, R.sup.2 en R.sup.3 zoals die in de specificatie zijn, en aan farmaceutische samenstellingen en methodes om ontsteking, kanker en andere wanorde wordt bepaald te behandelen.

 
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