The present invention provides methods and devices for detecting a target
nucleic acid molecule. A set of oligonucleotide probes integrated into an
electric circuit, where the oligonucleotide probes are positioned such
that they can not come into contact with one another, are contacted with a
sample. If the sample contains a target nucleic acid molecule, one which
has sequences complimentary to both probes, the target nucleic acid
molecule can bridge the gap between the probes. The resulting bridge can
then carry electrical current between the two probes, indicating the
presence of the target nucleic acid molecule.