2'-O-Modified ribosyl nucleosides and modified oligomeric compounds containing such nucleosidic monomers are disclosed. Oligomeric compounds are disclosed that have increased binding affinity as shown by molecular modeling experiments. The 2'-O-modified nucleosides of the invention include ring structures that position the sugar moiety of the nucleosides preferentially in 3' endo geometries.

показаны нуклеозиды ribosyl 2'-O-Modified и доработанные олигомерные смеси содержа такие nucleosidic мономеры. Олигомерные смеси показаны увеличивали binding сродство как показано молекулярными моделируя экспериментами. Нуклеозиды 2'-O-modified вымысла вклюают структуры кольца располагают moiety сахара нуклеозидов преференциально в geometries endo 3'.

 
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