The present invention relates to viral mutants and methods of using these viral mutants for selectively killing neoplastic cells. The viral mutants of the invention are capable of selectively killing neoplastic cells by a combination of viral mediated oncolysis and anti-cancer ("suicide") gene therapy.

De onderhavige uitvinding heeft op virale mutanten en methodes om deze virale mutanten te gebruiken voor selectief het doden van neoplastic cellen betrekking. De virale mutanten van de uitvinding kunnen neoplastic cellen door een combinatie van virale bemiddelde oncolysis en ("zelfmoord") gentherapie selectief doden tegen kanker.

 
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