This invention relates to a fluorescence-mediated molecular tomographic imaging system, designed to detect near-infrared fluorescence activation in deep tissues. The system can use targeted fluorescent molecular probes or highly sensitive activatable fluorescence molecular probes. Such probes add molecular specificity and yield high fluorescence contrast, to allow early detection and molecular target assessment of diseased tissue, such as cancers, in vivo. The new tomographic imaging system enables three-dimensional localization in deep tissues and quantitation of molecular probes.

Esta invenção relaciona-se a um sistema tomográfico molecular fluorescence-mediado da imagem latente, projetado detectar a ativação próximo-infravermelha do fluorescence em tecidos profundos. O sistema pode usar pontas de prova molecular fluorescentes alvejadas ou pontas de prova molecular do fluorescence activatable altamente sensível. Tais pontas de prova adicionam o specificity molecular e rendem o contraste elevado do fluorescence, para permitir a deteção adiantada e a avaliação molecular do alvo de tecido doente, tal como cancers, em vivo. O sistema tomográfico novo da imagem latente permite o localization tridimensional em tecidos profundos e em quantitation de pontas de prova molecular.

 
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