Human immunodeficiency virus (HIV) comprising reverse transcriptase
inactivated by photoinactivation. The inactivated virus may be more safely
handled, stored, and analyzed, used in diagnostic procedures and kits, and
may be used as an immunogen to evoke an immune response. The immune
response may protect an individual from challenges with live virus.
Alternatively, the inactivated HIV particles may be used to augment the
immune response to HIV in an infected individual.