The present invention provides mutant presenilin 1 and presenilin 2 polpeptides and polynucleotides encoding the polypeptides and methods for their production by recombinant and PCR techniques are disclosed. Methods for utilizing the mutant polypeptides in screens for inhibitors of activity are also disclosed.

La actual invención proporciona el presenilin 1 del mutante y se divulga el presenilin 2 polpeptides y polynucleotides que codifican los polipéptidos y los métodos para su producción por técnicas recombinant y de PCR. Los métodos para utilizar los polipéptidos del mutante en las pantallas para los inhibidores de la actividad también se divulgan.

 
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