The invention provides lipophilic phosphonoacid/nucleoside conjugates that exhibit exceptional antiviral activity, including activity against drug-resistant HIV strains. Compounds of the invention include phosphonoacid/nucleoside conjugates where the carboxyl group and phosphonyl groups of the phosphonacid are esterified whereby the compound contains at least one lipophilic group and at least one nucleoside group.

De uitvinding verstrekt lipophilic phosphonoacid/nucleosidestamverwanten die uitzonderlijke antiviral activiteit, met inbegrip van activiteit tegen drug-resistant HIV spanningen tentoonstellen. De samenstellingen van de uitvinding omvatten phosphonoacid/nucleosidestamverwanten waar de carboxyl groep en de phosphonylgroepen phosphonacid worden geëstrificeerd waardoor de samenstelling minstens één lipophilic groep en minstens één nucleosidegroep bevat.

 
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