The present invention provides methods of modulating neurotrophic
factor-associated activity, especially CNTF-associated levels and
activity, using aldose reductase inhibitors. These methods are especially
useful in individuals suffering from, or at risk of developing,
neurological disorders, including neurodegenerative disorders. The
invention also provides methods of palliating neurological disorders and
delaying development of neurological disorders using aldose reductase
inhibitors.
