A multiple level micro-array system for integrating micro-arrays of
biomolecules, including biological, chemical and biochemical elements. The
multiple level micro-arrays are formed using soft lithography techniques
and elastomeric membranes to shield or pattern various portions of a
suitable substrate with biomolecules. Additional levels are formed using
membranes with various through holes which either isolate, stratify or
shield the patterned biomolecules from subsequent patterning or addition
of an assay solution.