Compounds having Formula I, including pharmaceutically acceptable salts,
hydrates and solvates thereof:
##STR1##
are selective inhibitors of the 11.beta.-HSD1 enzyme. The compounds are
useful for the treatment of diabetes, such as noninsulin-dependent
diabetes (NIDDM), hyperglycemia, obesity, insulin resistance,
dylsipidemia, hyperlipidemia, hypertension, Syndrome X, and other symptoms
associated with NIDDM.
