Macrophage derived chemokine (MDC) and chemokine analogs and assay to identify modulators of MDC activity, and therapeutic uses for same

   
   

The present invention provides purified and isolated polynucleotide sequences encoding a novel human macrophage-derived C-C chemokine designated Macrophage Derived Chemokine (MDC), and polypeptide analogs thereof Also provided are materials and methods for the recombinant production of the chemokine, and purified and isolated chemokine protein, and polypeptide analogs thereof. Also provided are antibodies reactive with the chemokine and methods of making and using all of the foregoing.

La actual invención proporciona las secuencias purificadas y aisladas del polynucleotide que codifican una novela cc macro'fago-derivado humano Chemokine derivado macrófago señalado chemokine (MDC), y los análogos del polipéptido de eso también proporcionados son materiales y métodos para la producción recombinant del chemokine, y proteína purificada y aislada del chemokine, y análogos del polipéptido de eso. También se proporcionan los anticuerpos reactivos con el chemokine y los métodos de hacer y de usar todo del precedente.

 
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