Novel five-membered heterocyclic amidines, their preparation and use as
competitive inhibitors of trypsin-like serine proteases, especially
thrombin and kininogenases such as kallikrein. Pharmaceutical compositions
which contain the compounds as active ingredients, and use of the
compounds as thrombin inhibitors, anticoagulants and antiinflammatory
agents.
A novela five-membered amidines heterocyclic, seu preparação e uso como inibidores do competidor trypsin-como de proteases do serine, especial thrombin e kininogenases tais como o kallikrein. Composições pharmaceutical que contêm os compostos como ingredientes ativos, e uso dos compostos como inibidores do thrombin, anticoagulants e agentes antiinflammatory.
