Indole derivatives represented by formula (I):
##STR1##
(wherein all symbols are described in the description), a process for the
preparation of the same and a DP receptor antagonist comprising it as an
active ingredient. Since the compounds of formula (I) binds to and are
antagonistic to a DP receptor, they are useful in for the prevention
and/or treatment of diseases, for example, allergic diseases (allergic
rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma,
food allergy, etc., systemic mastocytosis; disorders due to systemic
mastocyte activation, anaphylactic shock, bronchoconstriction, urticaria,
eczema, etc.), diseases accompanied with itching (atopic dermatitis,
urticaria, etc.), secondary diseases caused by behaviors (scratching
behaviors, beating, etc.) (cataract, retinal detachment, inflammation,
infection, sleep disorder, etc.), inflammation, chronic obstructive
pulmonary disease, ischemic reperfusion disorder, cerebrovascular
disorder, pleuritis complicated by rheumatoid arthritis, ulcerative
colitis, and the like.
Derivatives do indole representados pela fórmula (i): ## do ## STR1 (wherein todos os símbolos são descritos na descrição), um processo para a preparação do mesmo e um antagonista do receptor do DP que compreende a como um ingrediente ativo. Desde que os compostos da fórmula (I) ligam a e são antagonistic a um receptor do DP, são úteis dentro para a prevenção e/ou o tratamento das doenças, para o exemplo, de doenças allergic (rhinitis allergic, do conjunctivitis allergic, da dermatite atópica, do asthma bronchial, do allergy do alimento, etc., mastocytosis systemic; disorders devido à ativação systemic do mastocyte, a choque anafiláctico, ao bronchoconstriction, ao urticaria, ao eczema, etc.), doenças acompanhadas com itching (dermatite atópica, urticaria, etc.), doenças secundárias causadas pelos comportamentos (que riscam comportamentos, batida, etc..) (cataract, destacamento retinal, inflammation, infecção, disorder do sono, etc.), inflammation, doença pulmonary obstructive crônica, disorder isquêmico do reperfusion, disorder cerebrovascular, pleuritis complicados pelo arthritis rheumatoid, colitis ulcerative, e o gosto.
