Topical patch preparations that contain a delayed-type hypersensitivity
inducer, e.g., 1-dichloro-2,4-dinitrobenzene (DNCB), and methods for using
the same are provided. The subject topical patch preparations are made up
of an adhesive gel composition that is present on a support, where the
adhesive gel composition includes the delayed-type hypersensitivity
inducer, a water-soluble polymer gel, water and a water holding agent. In
using the subject topical patch preparations, the topical patch
preparations are applied to a skin surface of a subject and maintained at
the site of application for a period of time sufficient for an effective
amount of the delayed-type hypersensitivity inducer to be administered to
the subject, where this maintenance period typically does not exceed about
60 minutes. The subject invention finds use in a variety of applications
where the administration of a delayed-type hypersensitivity inducer is
desired, and is particularly suited for use in the treatment of HIV
associated disease conditions, e.g., AIDS.
