The present invention relates to novel Death Domain Containing Receptor
(DR3 and DR3-V1) proteins which are members of the tumor necrosis factor
(TNF) receptor family. In particular, isolated nucleic acid molecules are
provided encoding the human DR3 and DR3-V1 proteins. DR3 and DR3-V1
polypeptides are also provided, as are vectors, host cells and recombinant
methods for producing the same. The invention further relates to screening
methods for identifying agonists and antagonists of DR3 and DR3-V1
activity.
