A novel cytokine, designated Apo-2 ligand, which induces mammalian cell
apoptosis is provided. The Apo-2 ligand is believed to be a member of the
TNF cytokine family. Compositions including Apo-2 ligand chimeras, nucleic
acid encoding Apo-2 ligand, and antibodies to Apo-2 ligand are also
provided. Methods of using Apo-2 ligand to induce apoptosis and to treat
pathological conditions such as cancer, are further provided.
Um cytokine da novela, designado o ligand Apo-2, que induz o apoptosis da pilha mammalian são fornecidos. O ligand Apo-2 é acreditado para ser um membro da família do cytokine de TNF. As composições including chimeras do ligand Apo-2, o ácido nucleic que codificam o ligand Apo-2, e os antibodies ao ligand Apo-2 são fornecidas também. Os métodos de usar o ligand Apo-2 induzir o apoptosis e tratar condições pathological tais como o cancer, são fornecidos mais mais.
