The present invention relates to methods of treating disorders related to
cellular overproliferation comprising neutralizing the production or
activity of macrophage migration inhibitory factor (MIF). The invention
also relates to therapeutic compositions comprising factors which inhibit
or neutralize MIF activity, such as, MIF antisense RNA molecules and MIF
monoclonal antibodies and derivatives or analogs thereof. The invention
further relates to the uses of such compositions and methods for the
treatment of malignancies, including, but not limited to, B and T cell
lymphomas.
