Semi-synthesis of a protected baccatin III compound

   
   

The present invention relates to a semi-synthetic process to convert a naturally occurring taxane into a suitable starting material for the synthesis of paclitaxel and related compounds. Specifically, the present invention relates to a process for the conversion of 9-dihydro-13-acetylbaccatin III into a 7-protected baccatin III which can then be used as starting material for the synthesis of taxane derivatives such as paclitaxel, docetaxel, cephalomannine and other taxanes structurally related to baccatin III. The method as described uses a preparative scale technique which is amenable to commercial scale-up.

La presente invenzione riguarda un processo semisintetico per convertire un taxane naturale in prodotto base adatto per la sintesi di paclitaxel e dei residui riferiti. Specificamente, la presente invenzione riguarda un processo per la conversione di 9-diidro-13-acetylbaccatin III 7-protected in un baccatin III che può allora essere usato come prodotto base per la sintesi dei derivati del taxane quali paclitaxel, docetaxel, il cephalomannine ed altri taxanes relativi strutturalmente al baccatin III. Il metodo come usi che descritti una tecnica preparatoria della scala che è favorevole a commerciale regola -in su.

 
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