The present invention concerns an unexpected synergistic combination of
known antineoplastic agents which provides unexpectedly greater efficacy
than the single agents alone. Accordingly, the present invention provides
a method of treating neoplasia in a subject in need of treatment, by
administering to the subject an amount of paclitaxel effective to treat
the neoplasia, in combination with an amount of discodermolide effective
to treat the neoplasia, wherein a synergistic antineoplastic effect
results. The present invention further provides a synergistic combination
of antineoplastic agents, comprising an effective antineoplastic amount of
paclitaxel and an effective antineoplastic amount of discodermolide.
