Disclosed are compounds represented by formula (I) which have triglyceride
biosynthesis inhibitory activity in the liver and inhibitory activity
against the secretion of apolipoprotein B-containing lipoprotein from the
liver and particularly have excellent inhibitory activity against the
secretion of apolipoprotein B-containing lipoprotein, are free from side
effect of accumulation of lipids in the liver, and are useful for the
treatment and prevention of hyperlipidemia and arteriosclerotic diseases.
In formula (I), R.sup.1 and R.sup.2 represent alkyl, alkoxy, cycloalkyl,
phenyl, alkenyl, alkynyl, or a five- or six-membered saturated or
unsaturated heterocyclic ring, or R.sup.1 and R.sup.2, together with a
nitrogen atom to which R.sup.1 and R.sup.2 are attached, may form a ring;
R.sup.3 and R.sup.4 represent a hydrogen atom, alkyl, a halogen atom,
hydroxyl, nitrile, alkoxycarbonyl, alkoxy, or carboxyl; or R.sup.2 and
R.sup.3 may be attached to each other to form --(CH.sub.2).sub.m --,
--N.dbd.CH--, --CH.dbd.N--, or --(C.sub.1-6 alkyl)C.dbd.N--; A, D, E, and
G each represent a carbon atom, or any one of A, D, E, and G represents a
nitrogen atom with the other three each representing a carbon atom; Q
represents a nitrogen atom or a carbon atom; Y represents a group
represented by formula (II) wherein X represents a hydrogen atom, group
--C(.dbd.O)N(R.sup.5)R.sup.6 or group --C(.dbd.O)OR.sup.7, R.sup.8 is
absent or represents a bond, an oxygen atom, a sulfur atom, --SO.sub.2 --,
--SO--, --CH.sub.2 --CH.sub.2 --, or --CH.dbd.CH--, and R.sup.9 and
R.sup.10 represent a hydrogen atom, alkyl, alkoxy, a halogen atom, or
hydroxyl; and Z represents --(CH.sub.2).sub.n --, --O--(CH.sub.2).sub.i
--, or --C(.dbd.O)NH--(CH.sub.2).sub.i --.
##STR1##
