The invention provides a peptide immunogen comprising a FAFSD target
peptide or an anlogue thereof, covalently linked to a helper T cell
epitope and optionally to an invasin immunostimulatory domain. The present
invention also provides for the use of such peptide immunogens to elicit
the production in mammals of high titer polyclonal antibodies, which are
specific to the FAFSD target peptide. The peptide immunogens are expected
to be useful in evoking antibodies that prevent the adherence of E. coli
and other enterobacteria to the bladder mucosa for protection against
urinary tract infection.
