Non-human mammalian animals having a higher epidermal expression level
of protein kinase C than their wild-type counterparts are phenotypically
distinguished from wild-type animals in that the animals induced to develop tumors
in a chemical initiation/promotion protocol are suppressed for subsequent papilloma
development but are susceptible to developing squamous cell carcinoma and metastatic
squamous cell carcinoma. The animals are advantageously used in methods for screening
putative agents for altering the susceptibility, development and progression of
squamous cell carcinoma and metastatic squamous cell carcinoma and have further
commercial value as tools for investigating the development of metastatic disease.
