Disclosed is the surprising discovery that aminophospholipids, such as
phosphatidylserine and phosphatidylethanolamine, are specific, accessible
and stable markers of the luminal surface of tumor blood vessels. The
present invention thus provides aminophospholipid-targeted diagnostic and
therapeutic constructs for use in tumor intervention. Antibody-therapeutic
agent conjugates and constructs that bind to aminophospholipids are
particularly provided, as are methods of specifically delivering
therapeutic agents, including toxins and coagulants, to the
stably-expressed aminophospholipids of tumor blood vessels, thereby
inducing thrombosis, necrosis and tumor regression.
É divulgado a descoberta surpreender que os aminophospholipids, tais como o phosphatidylserine e o phosphatidylethanolamine, são marcadores do específico, os acessíveis e os estáveis da superfície do luminal de embarcações de sangue do tumor. A invenção atual fornece assim construções diagnósticas e therapeutic aminophospholipid-alvejadas para o uso na intervenção do tumor. o agente Antibody-antibody-therapeutic conjugates e as construções que ligam aos aminophospholipids são fornecidas particularmente, como seja métodos especificamente de entregar agentes therapeutic, including toxins e coagulants, aos aminophospholipids estável-expressados de embarcações de sangue do tumor, induzindo desse modo o thrombosis, o necrosis e a regressão do tumor.
