The present invention provides methods of treating and preventing mortality
associated with heart failure in an African American patient with
hypertension, and improving oxygen consumption, quality of life and
exercise tolerance by administering a therapeutically effective amount of
at least one hydralazine compound and at least one of isosorbide dinitrate
and isosorbide mononitrate, and, optionally, one or more compounds, such
as, for example, a digitalis, a diuretic compound, or a compound used to
treat cardiovascular diseases. In the present invention, the hydralazine
compound is preferably hydralazine or a pharmaceutically acceptable salt
thereof. Preferred methods of the invention comprise administering
hydralazine or a pharmaceutically acceptable salt thereof and isosorbide
dinitrate.
