Antagonists of MCP-1 function and methods of use thereof

   
   

Compounds which are antagonists of MCP-1 function and are useful in the prevention or treatment of chronic or acute inflammatory or autoimmune diseases, especially those associated with aberrant lymphocyte or monocyte accumulation such as arthritis, asthma, atherosclerosis, diabetic nephropathy, inflammatory bowel disease, Crohn's disease, multiple sclerosis, nephritis, pancreatitis, pulmonary fibrosis, psoriasis, restenosis, and transplant rejection; pharmaceutical compositions comprising these compounds; and the use of these compounds and compositions in the prevention or treatment of such diseases.

Combina que são antagonistas da função MCP-1 e são útil na prevenção ou no tratamento de doenças inflammatory ou autoimmune crônicas ou agudas, especial aquelas associadas com a acumulação aberrant do lymphocyte ou do monocyte tal como o arthritis, o asthma, o atherosclerosis, o nephropathy diabetic, a doença inflammatory do bowel, a doença de Crohn, o sclerosis múltiplo, o nephritis, o pancreatitis, o fibrosis pulmonary, o psoriasis, o restenosis, e a rejeção do transplant; composições pharmaceutical que compreendem estes compostos; e o uso destes compostos e composições na prevenção ou no tratamento de tais doenças.

 
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