Compounds which are antagonists of MCP-1 function and are useful in the
prevention or treatment of chronic or acute inflammatory or autoimmune
diseases, especially those associated with aberrant lymphocyte or monocyte
accumulation such as arthritis, asthma, atherosclerosis, diabetic
nephropathy, inflammatory bowel disease, Crohn's disease, multiple
sclerosis, nephritis, pancreatitis, pulmonary fibrosis, psoriasis,
restenosis, and transplant rejection; pharmaceutical compositions
comprising these compounds; and the use of these compounds and
compositions in the prevention or treatment of such diseases.
Combina que são antagonistas da função MCP-1 e são útil na prevenção ou no tratamento de doenças inflammatory ou autoimmune crônicas ou agudas, especial aquelas associadas com a acumulação aberrant do lymphocyte ou do monocyte tal como o arthritis, o asthma, o atherosclerosis, o nephropathy diabetic, a doença inflammatory do bowel, a doença de Crohn, o sclerosis múltiplo, o nephritis, o pancreatitis, o fibrosis pulmonary, o psoriasis, o restenosis, e a rejeção do transplant; composições pharmaceutical que compreendem estes compostos; e o uso destes compostos e composições na prevenção ou no tratamento de tais doenças.
