Process for preparing functionalized polyalkyleneimines, compositions containing them and uses thereof

   
   

The present invention relates to a process for preparing functionalized polyalkyleneimines which are useful for formulating nucleic acids intended to be transfected into cells. This process consists in treating polyalkyleneimines with a functionalized hemiacetal in the presence of titanium (IV) isopropoxide and sodium borohydride.

De onderhavige uitvinding heeft op een proces om voorbereidingen te treffen betrekking functionalized polyalkyleneimines die nuttig zijn om nucleic zuren te formuleren die bedoelen als om transfected in cellen. Dit proces bestaat uit het behandelen van polyalkyleneimines met a functionalized hemiacetal in aanwezigheid van titanium(iv) isopropoxide en natriumborohydride.

 
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