Immunomodulation by genetic modification of dendritic cells and B cells

   
   

The present invention provides a CD40-targeted gene delivery system and a CD40-targeted recombinant adenoviral vector for genetic manipulation of dendritic cells and B cells. Also provided are methods of using this enhanced gene delivery to immune system cells and therefore, enhancing dendritic cell-based immunotherapy.

A invenção atual fornece um sistema da entrega do gene de CD40-targeted e um vetor adenoviral recombinant de CD40-targeted para a manipulação genetic de pilhas dendritic e de pilhas de B. São fornecidos também os métodos de usar isto entrega realçada do gene às pilhas do sistema imune e conseqüentemente, realçando o immunotherapy cell-based dendritic.

 
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