Macrocyclic NS3-serine protease inhibitors of hepatitis C virus comprising N-cyclic P2 moieties

   
   

The present invention discloses novel macrocyclic compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such macrocycles as well as methods of using them to treat disorders associated with the HCV protease.

A invenção atual divulga os compostos macrocyclic da novela que têm a atividade inhibitory do protease de HCV as.well.as métodos para preparar tais compostos. Em uma outra incorporação, a invenção divulga as composições pharmaceutical que compreendem tais macrocycles as.well.as métodos de usá-los tratar os disorders associados com o protease de HCV.

 
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< Hepatitis C inhibitor compound

< Substituted cycloalkyl P1' hepatitis C virus inhibitors

> Ribavirin-interferon alfa combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis C infection

> Alpha-ketoamide inhibitors of hepatitis C virus NS3 protease

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