Muteins of hypoxia inducible factor alpha and methods of use thereof

   
   

The present invention provides hypoxia inducible factor alpha muteins, DNA sequences encoding these hypoxia inducible factor alpha muteins, recombinant DNA molecules containing those DNA sequences operatively linked to expression control sequences and capable of inducing expression of an hypoxia inducible factor alpha muteins, hosts transformed with those recombinant DNA molecules, pharmaceutical compositions containing hypoxia inducible factor alpha muteins and methods of using those compositions to treat hypoxia and ischemic related tissue damage.

A invenção atual fornece muteins inducible do alfa do fator do hypoxia, o DNA arranja em seqüência codificar estes muteins inducible do alfa do fator do hypoxia, moléculas recombinant do DNA que contêm aquelas seqüências do DNA ligadas operativa às seqüências de controle da expressão e capaz de induzir a expressão de muteins inducible de um alfa do fator do hypoxia, anfitriões transformados com aquelas moléculas recombinant do DNA, composições pharmaceutical que contêm muteins do alfa do fator do hypoxia e métodos inducible de usar aquelas composições tratar o hypoxia e o tecido relacionado isquêmico danifique.

 
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