6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines page

6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines

The present invention relates to compounds which are capable of preventing the extracellular release of inflammatory cytokines, said compounds, including all enantiomeric and diasteriomeric forms and pharmaceutically acceptable salts thereof, have the formula: ##STR1## wherein R.sup.1 is substituted aryl; R.sup.4 is substituted or unsubstituted aryl or heteroaryl.

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< Pyridin-4-YL or pyrimidin-4-YL substituted pyrazines

< 4-aryl substituted indolinones

> Nucleosidic and non-nucleosidic folate conjugates

> Acyl and sulfonyl derivatives of 6,9-disubstituted 2-(trans-1,4-diaminocyclohexyl)-purines and their use as antiproliferative agents

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