Disclosed is a method of small particle precipitation, retention and
dispersion of a solid or semi-solid material onto or into a carrier
material. In this method, solute particles are precipitated from a
pressurized gaseous fluid solution or a liquid solution and effectively
retained and dispersed within a carrier material. This technique can be
advantageously used in pharmaceutical processing to produce a blend of
solid or semi-solid material particles and carrier material, a granulation
of the solid or semi-solid material particles with carrier material,
carrier material partially or fully coated with the solid or semi-solid
material particles, or mixtures thereof.
