Compounds of formula (I) wherein R.sub.1 is selected from H, C(.dbd.O)R',
P(.dbd.O)R'R", S(.dbd.O)R'R", substituted or unsubstituted C.sub.1
-C.sub.18 alkyl, substituted or unsubstituted C.sub.2 -C.sub.18 alkenyl,
substituted or unsubstituted C.sub.2 -C.sub.18 alkynyl, or substituted or
unsubstituted aryl; or R.sub.1 together with R.sub.2 forms a saturated or
unsaturated heterocyclic ring; R.sub.2 and R.sub.3 are each,
independently, selected from H, C(.dbd.O)R', P(.dbd.O)R'R", S(.dbd.O)R'R",
substituted or unsubstituted C.sub.1 -C.sub.18 alkyl, substituted or
unsubstituted C.sub.2 -C.sub.18 alkenyl, substituted or unsubstituted
C.sub.2 -C.sub.18 alkynyl, or substituted or unsubstituted aryl; or one of
R.sub.2 or R.sub.3 together with R.sub.1 forms a saturated or unsaturated
heterocyclic ring; or R.sub.2 and R.sub.3 together form a saturated or
unsaturated heterocyclic ring; R.sub.4 is selected from H, C(.dbd.O)R',
P(.dbd.O)R'R", S(.dbd.O)R'R", substituted or unsubstituted C.sub.1
-C.sub.18 alkyl, substituted or unsubstituted C.sub.2 -C.sub.18 alkenyl,
substituted or unsubstituted C.sub.2 -C.sub.18, alkynyl, or substituted or
unsubstituted aryl, wherein R' is selected from the group consisting of H,
OH, NO.sub.2, NH.sub.2, SH, CN, halogen, C(.dbd.O)H, C(.dbd.O)CH.sub.3,
CO.sub.2 H, CO.sub.2 CH.sub.3, substituted or unsubstituted C.sub.1
-C.sub.18 alkyl, substituted or unsubstituted C.sub.2 -C.sub.18 alkenyl,
substituted or unsubstituted C.sub.2 -C.sub.18 alkynyl, substituted and
unsubstituted aryl; R" is selected from the group consisting of H, OH,
NO.sub.2, NH.sub.2, SH, CN, halogen, .dbd.O, C(.dbd.O)H,
C(.dbd.O)CH.sub.3, CO.sub.2 H, CO.sub.2 CH.sub.3, substituted or
unsubstituted C.sub.1 -C.sub.18 alkyl, substituted or unsubstituted
C.sub.2 -C.sub.18 alkenyl, substituted or unsubstituted C.sub.2 -C.sub.18
alkynyl, substituted and unsubstituted aryl; wherein X.sub.1, X.sub.2
X.sub.3 on formula I are independently placed in any particular position
of the chain and independently selected from H, OH, OR', SH, SR', SOR',
SO.sub.2 R', NO.sub.2, NH.sub.2, NHR', N(R').sub.2, NHC(O)R', CN, halogen,
.dbd.O, C(.dbd.O)H, C(.dbd.O)CH.sub.3, CO.sub.2 H, CO.sub.2 CH.sub.3,
substituted or unsubstituted C.sub.1 -C.sub.18 alkyl, substituted or
unsubstituted C.sub.2 -C.sub.18 alkenyl, substituted or unsubstituted
C.sub.2 -C.sub.18 alkynyl, substituted or unsubstituted aryl, substituted
or unsubstituted heteroaromatic, wherein substituent groups defined by R'
are each independently selected from the group consisting of H, OH, OR',
SH, SR', SOR', SO.sub.2 R', NO.sub.2, NH.sub.2, NHR', N(R').sub.2,
NHC(O)R', CN, halogen, .dbd.O, C(.dbd.O)H, C(.dbd.O)CH.sub.3, CO.sub.2 H,
CO.sub.2 CH.sub.3, substituted or unsubstituted C.sub.1 -C.sub.18 alkyl,
substituted or unsubstituted C.sub.2 -C.sub.18 alkenyl, substituted or
unsubstituted C.sub.2 -C.sub.18 alkynyl, substituted or unsubstituted
aryl, and substituted or unsubstituted heteroaromatic; wherein x is 6 to
20; and wherein the dotted lined is one or several optional double bonds
placed in any particular position of the side chain; or pharmaceutically
acceptable salts thereof are useful as antitumor compounds and include
compound IK-8-73-4 of structure (a) which was isolated from a sponge
Pachastrissa sp.
##STR1##
Compuestos de C.sub.1 del fórmula (i) en donde R.sub.1 se selecciona de H, C(.dbd.O)R ', P(.dbd.O)R'R ", de S(.dbd.O)R'R", substituido o sin sustituir - C.sub.2 substituido o sin sustituir del alkyl C.sub.18, - C.sub.2 alkenyl, substituido o sin sustituir de C.sub.18 - alkynyl C.sub.18, o aryl substituido o sin sustituir; o R.sub.1 junto con R.sub.2 forma un anillo heterocíclico saturado o no saturado; R.sub.2 y R.sub.3 son cada uno, seleccionado independientemente de H, C.sub.1 substituido o sin sustituir de C(.dbd.O)R ', de P(.dbd.O)R'R ", de S(.dbd.O)R'R", substituido o sin sustituir - del alkyl C.sub.18, C.sub.2 - C.sub.2 alkenyl, substituido o sin sustituir de C.sub.18 - alkynyl C.sub.18, o aryl substituido o sin sustituir; o uno de R.sub.2 o de R.sub.3 junto con R.sub.1 forma un anillo heterocíclico saturado o no saturado; o R.sub.2 y R.sub.3 juntos forman un anillo heterocíclico saturado o no saturado; R.sub.4 se selecciona de C.sub.1 de H, de C(.dbd.O)R ', de P(.dbd.O)R'R ", de S(.dbd.O)R'R", substituido o sin sustituir - C.sub.2 substituido o sin sustituir del alkyl C.sub.18, - C.sub.2 alkenyl, substituido o sin sustituir de C.sub.18 - C.sub.18, alkynyl, o C.sub.1 substituido o sin sustituir del aryl, en donde R ' se selecciona del grupo que consiste en H, OH, NO.sub.2, NH.sub.2, SH, de CN, del halógeno, de C(.dbd.O)H, de C(.dbd.O)CH.sub.3, de CO.sub.2 H, de CO.sub.2 CH.sub.3, haber substituido o sin sustituir - C.sub.2 del alkyl C.sub.18, substituido o sin sustituir - C.sub.2 alkenyl, substituido o sin sustituir de C.sub.18 - aryl del alkynyl C.sub.18, substituido y sin sustituir; R substituido o sin sustituir "se selecciona del grupo que consiste en H, el OH, NO.sub.2, NH.sub.2, C.sub.1 SH, de CN, del halógeno, del dbd.O, de C(.dbd.O)H, de C(.dbd.O)CH.sub.3, de CO.sub.2 H, de CO.sub.2 CH.sub.3, haber substituido o sin sustituir - del alkyl C.sub.18, C.sub.2 - C.sub.2 alkenyl, substituido o sin sustituir de C.sub.18 - aryl del alkynyl C.sub.18, substituido y sin sustituir; en donde X.sub.1, X.sub.2 X.sub.3 en el fórmula I se colocan independientemente en cualquier posición particular de la cadena y se seleccionan independientemente de H, del OH, O ', de SH, del SR ', del sor ', de SO.sub.2 R ', de NO.sub.2, de NH.sub.2, de NHR ', de N(R').sub.2, de C.sub.1 de NHC(O)R ', de CN, del halógeno, del dbd.O, de C(.dbd.O)H, de C(.dbd.O)CH.sub.3, de CO.sub.2 H, de CO.sub.2 CH.sub.3, haber substituido o sin sustituir - C.sub.2 alkyl, substituido o sin sustituir de C.sub.18 - C.sub.2 alkenyl, substituido o sin sustituir de C.sub.18 - heteroaromatic aryl, substituida o sin sustituir del alkynyl C.sub.18, substituido o sin sustituir, en donde los grupos del sustituto definidos por R ' son cada uno seleccionado independientemente del grupo que consiste en H, Oh, O ', SH, SR ', sor ', SO.sub.2 R ', NO.sub.2, NH.sub.2, NHR ', N(R').sub.2, C.sub.1 de NHC(O)R ', de CN, del halógeno, del dbd.O, de C(.dbd.O)H, de C(.dbd.O)CH.sub.3, de CO.sub.2 H, de CO.sub.2 CH.sub.3, haber substituido o sin sustituir - C.sub.2 del alkyl C.sub.18, substituido o sin sustituir - C.sub.2 alkenyl, substituido o sin sustituir de C.sub.18 - aryl substituido o sin sustituir del alkynyl C.sub.18, y heteroaromatic substituida o sin sustituir; en donde x es 6 a 20; y en donde punteado alineado es un o vario enlaces dobles opcionales puestos en cualquier posición particular de la cadena lateral; o las sales aceptables de eso son útiles como compuestos antitumor e incluyen farmacéutico IK-8-73-4 compuesto de la estructura (a) que fue aislada de un SP de Pachastrissa de la esponja. ## del ## STR1
