Compounds according formula (I) A-G-Z-W
and pharmaceutically acceptable salts, solvates or hydrates thereof;
wherein,
A is (C.sub.6-C.sub.10)aryl, (C.sub.6-C.sub.10)aryl-SO.sub.2,
(C.sub.6-C.sub.10)aryl-CH.sub.2--, (C.sub.6-C.sub.10)arylcarbonyl,
(C.sub.1-C.sub.9)heteroaryl, (C.sub.1-C.sub.9)heteroaryl-SO.sub.2--,
(C.sub.1-C.sub.9)heteroaryl-CH.sub.2--; or (C.sub.1-C.sub.9)heteroarylcar-
bonyl;
G is selected from the group consisting of: 1
where B is (C.sub.6-C.sub.10)aryl or (C.sub.1-C.sub.9)heteroaryl, and X is
CH.sub.2, SO.sub.2, or carbonyl; 2
where X is CH.sub.2, SO.sub.2, or carbonyl; and R.sup.1 and R.sup.1' are
each independently selected from H, CN, (C.sub.1-C.sub.8)alkyl-, and
phenyl(CH.sub.2)--, wherein said alkyl and phenyl groups are optionally
substituted; and 3
where Z and W are as defined in the present Specificiation; and
pharmaceutical compositions and methods useful to increase secretion of
growth hormone(GH) from the anterior pituitary of mammals, including on a
sustained release basis.
Compostos que concordam a fórmula (I) A-G-Z-W e pharmaceutically sais, solvates ou hydrates aceitáveis disso; wherein, A é (C.sub.6-C.sub.10)aryl, (C.sub.6-C.sub.10)aryl-SO.sub.2, (C.sub.6-C.sub.10)aryl-CH.sub.2 --. (C.sub.6-C.sub.10)arylcarbonyl, (C.sub.1-C.sub.9)heteroaryl, (C.sub.1-C.sub.9)heteroaryl-SO.sub.2 --. (--; C.sub.1-C.sub.9)heteroaryl-CH.sub.2 ou (bonyl de C.sub.1-C.sub.9)heteroarylcar-; G é selecionado de consistir do grupo: 1 onde B está (C.sub.6-C.sub.10)aryl ou (C.sub.1-C.sub.9)heteroaryl, e X é CH.sub.2, SO.sub.2, ou carbonyl; 2 onde X é CH.sub.2, SO.sub.2, ou carbonyl; e R.sup.1 e R.sup.1 ' são cada um selecionado independentemente de H, CN, (C.sub.1-C.sub.8)alkyl -, e phenyl(CH.sub.2) --. wherein o alkyl dito e os grupos phenyl são substituídos opcionalmente; e 3 onde Z e W são como definidos no Specificiation atual; e composições pharmaceutical e métodos úteis aumentar o secretion do hormone(GH) do crescimento do pituitary anterior dos mamíferos, incluindo em uma base sustentada da liberação.
