Process for the synthesis of atorvastatin form v and phenylboronates as intermediate compounds

   
   

The present invention discusses a novel process for the synthesis of [R-(R*,R*)]-2-(4-fluorophenyl)-B,D-dihydroxy-5-(1-methylethyl)-3-phenyl-4- [(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid hemi calcium, atorvastatin. The compound so prepared is useful as inhibitor of the HMG-CoA reductase and may thus be used as hypolipidemic and hypocholesterolemic agent.

Die anwesende Erfindung bespricht einen Romanprozeß für die Synthese von [ R-(R*, R*)]-2-(4-fluorophenyl)-B, D-dihydroxy-5-(1-methylethyl)-3-phenyl-4- [ (phenylamino)carbonyl]-1H-pyrrole-1-heptanoic saures hemi Kalzium, atorvastatin. Das Mittel also vorbereitet ist als Hemmnis der HMG-CoA Reduktase nützlich und kann als hypolipidemisches und hypocholesterolemisches Mittel folglich verwendet werden.

 
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