The invention relates to compounds of formula (I)
##STR1##
where
R.sub.1 represents a hydrogen or halogen atom or an --S(O).sub.z --(C.sub.1
-C.sub.4)alkyl, --S(O).sub.z --(C.sub.1 -C.sub.4)R.sub.3, --SO.sub.2
--NH--(C.sub.1 -C.sub.4)alkyl, --NHCO(C.sub.1 -C.sub.4) alkyl,
--CO(C.sub.1 -C.sub.4)alkyl or --NHSO.sub.2 --(C.sub.1 -C.sub.4)alkyl
group;
m and n independently represent 0, 1 or 2;
A represents a group of formula (a) or (b):
##STR2##
where
X is N or CH;
R.sub.2 represents an --SO.sub.2 --R.sub.3, --CO--R.sub.3 or --CO--(C.sub.1
-C.sub.4)--alkyl group;
R.sub.3 represents a phenyl group, optionally substituted by a (C.sub.1
-C.sub.4)alkyl or (C.sub.1 -C.sub.4)alkoxy group, one or two halogen atoms
or a heterocycle;
R.sub.4 represents a hydrogen or halogen atom or a (C.sub.1 -C.sub.6)alkyl,
(C.sub.1 -C.sub.4)alkoxy, --COOH, --COO(C.sub.1 -C.sub.4)alkyl, --CN,
--CONR.sub.5 R.sub.6, --NO.sub.2, --NHSO.sub.2 (C.sub.1 -C.sub.4)alkyl or
--SO.sub.2 NR.sub.5 R.sub.6 group;
z is 1 or 2;
R.sub.5 and R.sub.6 independently represent a hydrogen atom or a (C.sub.1
-C.sub.4)alkyl, phenyl or phenyl (C.sub.1 -C.sub.4)alkyl group;
and their salts or solvates, to a process for their preparation, to
synthetic intermediates and to the pharmaceutical compositions comprising
them.
La invención se relaciona con los compuestos del ## del ## STR1 del fórmula (i) donde R.sub.1 representa un átomo del hidrógeno o del halógeno o -- S(O).sub.z -- un (C.sub.1 - C.sub.4)alkyl, -- S(O).sub.z -- (C.sub.1 - C.sub.4)R.sub.3, -- SO.sub.2 -- NH -- (C.sub.1 -) alkyl C.sub.4)alkyl, -- NHCO(C.sub.1 - C.sub.4, -- CO(C.sub.1 - C.sub.4)alkyl o -- NHSO.sub.2 -- (C.sub.1 - grupo de C.sub.4)alkyl; m y n representan independientemente 0, 1 o 2; A representa un grupo del fórmula (a) o (b): ## del ## STR2 donde X es N o CH; R.sub.2 representa -- SO.sub.2 -- un R.sub.3, -- CO -- R.sub.3 o -- CO -- (C.sub.1 - C.sub.4) -- grupo alkyl; R.sub.3 representa a grupo fenilo, substituido opcionalmente por a (C.sub.1 - C.sub.4)alkyl o (C.sub.1 - grupo de C.sub.4)alkoxy, un o dos átomos del halógeno o un heterocycle; R.sub.4 representa un átomo o a (C.sub.1 - C.sub.6)alkyl del hidrógeno o del halógeno, (C.sub.1 - C.sub.4)alkoxy, -- cooh, -- COO(C.sub.1 - C.sub.4)alkyl, --CN, -- CONR.sub.5 R.sub.6, -- NO.sub.2, -- NHSO.sub.2 (C.sub.1 - C.sub.4)alkyl o -- grupo de SO.sub.2 NR.sub.5 R.sub.6; z es 1 o 2; R.sub.5 y R.sub.6 representan independientemente un átomo o una a (C.sub.1 del hidrógeno - C.sub.4)alkyl, fenilo o fenilo (C.sub.1 - grupo de C.sub.4)alkyl; y sus sales o solvates, a un proceso para su preparación, a los intermedios sintéticos y a las composiciones farmacéuticas que las abarcan.
