The present invention provides for pyridoxine phosphonate analogues such
as, for example,
((2-methyl-3-hydroxy-4-hydroxymethyl-5-pyridyl)alkylphosphonates, and
(2-methyl-3-hydroxy-4-hydroxymethyl-5-pyridyl)azaalkylphosphonates) and to
pyridoxine malonate analogues, such as, for example,
((2-methyl-3-hydroxy-4-hydroxymethyl-5-pyridylmethyl)malonates),
pharmaceutical compositions, and methods for treatment of cardiovascular
and related diseases, and diabetes mellitus and related diseases.
La présente invention prévoit des analogues de phosphonate de pyridoxine comme, par exemple, ((2-methyl-3-hydroxy-4-hydroxymethyl-5-pyridyl)alkylphosphonates, et (2-methyl-3-hydroxy-4-hydroxymethyl-5-pyridyl)azaalkylphosphonates) et aux analogues de malonate de pyridoxine, comme, par exemple, ((2-methyl-3-hydroxy-4-hydroxymethyl-5-pyridylmethyl)malonates), les compositions pharmaceutiques, et les méthodes pour le traitement des maladies cardiovasculaires et relatives, et du mellitus de diabète et des maladies relatives.
