GB virus C (GBV-C or hepatitis G virus) is a recently described flavivirus
that frequently leads to chronic viremia in humans. Although associated
with acute post-transfusion hepatitis, it is not clear if GBV-C is
pathogenic for humans. A full-length cDNA was constructed from the plasma
of a person with chronic GBV-C viremia. Peripheral blood mononuclear cells
(PBMCs) transfected with full-length RNA transcripts from this GBV-C clone
resulted in viral replication, demonstrating an isolated infectious GBV-C
nucleic acid molecule. In addition to composition involving an isolated
infectious GBV-C nucleic acid molecule, the present invention concerns
methods of inhibiting and treating HIV infections.
O vírus C do GB (GBV-C ou vírus de G do hepatitis) é um flavivirus recentemente descrito que conduza freqüentemente ao viremia crônico nos seres humanos. Embora associado com o hepatitis agudo do borne-post-transfusion, não está desobstruído se GBV-C for pathogenic para seres humanos. Um DNA full-length foi construído do plasma de uma pessoa com viremia crônico de GBV-C. O sangue que periférico as pilhas mononuclear (PBMCs) transfected com transcripts full-length do RNA deste clone de GBV-C resultou no replication viral, demonstrando uma molécula infectious isolada do ácido nucleic de GBV-C. Além à composição que envolve uma molécula infectious isolada do ácido nucleic de GBV-C, a invenção atual concerne métodos de inibir e de tratar infecções de HIV.
