Polycyclic aryl and heteroaryl substituted 4-pyrones useful for selective inhibition of the coagulation cascade

   
   

The invention relates to polycyclic aryl and heteroaryl substituted 4-pyrone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.

Вымысел относит к полициклическому арилу и 4-pyrone замененное heteroaryl смешивает полезно по мере того как иы АБС битор протеаз серина свертывания каскадируют и смеси, составы и методы для терапии противокоагулятора для обработки и предохранения разнообразия thrombotic условий включая коронарную артерию и цереброваскулярные заболевания.

 
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