Generation of diversity in combinatorial libraries

   
   

The invention concerns gene banks and combinatorial derivatives thereof, prepared using phagemid- or phage-display in combination with type IIS restriction enzymes and cosmid packaging; their use for the isolation of ligands, including enzyme inhibitors, agonists and antagonists for receptors, competitive binding peptides to a defined target, diagnostic ligands for diseases and autoimmune syndromes, including surveillance tools for immune status, post-translationally modified peptides, and such ligands generated by this technology.

La banca del gene di preoccupazioni di invenzione ed i derivati combinatori di ciĆ², preparato usando il phagemid- o dei fagi-visualizzano congiuntamente a tipo imballaggio degli enzimi e del cosmid di limitazione di IIS; il loro uso per l'isolamento dei ligands, compreso gli inibitori di enzimi, degli agonisti e degli antagonisti per i ricevitori, peptidi obbligatori competitivi ad un obiettivo definito, ligands diagnostici per le malattie e sindromi autoimmuni, compreso gli attrezzi di sorveglianza per condizione immune, i peptidi modificati alberino-translationally e tali ligands generati da questa tecnologia.

 
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