Chimeric Galpha 15 variants and their use in the analysis and discovery of modulators of G-protein coupled receptors

   
   

The invention provides a series of chimeric G.sub..alpha.15 protein variants that couple to certain GPCRs more efficiently than the native G.alpha..sub.15 protein. These chimeric G.sub..alpha.15 protein variants can be used to discover and analyze modulators of GPCRs (especially those that mediate taste perception).

La invención proporciona una serie de variantes quiméricas de la proteína G.sub..alpha.15 que se junten a cierto GPCRs más eficientemente que la proteína nativa G.alpha..sub.15. Estas variantes quiméricas de la proteína G.sub..alpha.15 se pueden utilizar para descubrir y para analizar los moduladores de GPCRs (especialmente los que median la opinión de gusto).

 
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