3,5 disubstituted indazole compounds with substituted nitrogen bearing
5-membered heterocycles in the 3-position that modulate and/or inhibit
cell proliferation, such as the activity of protein kinases are
described. These compounds and pharmaceutical compositions containing
them are capable of mediating CDK dependent diseases to modulate and/or
inhibit unwanted cell proliferation. The invention is also directed to
the therapeutic or prophylactic use of pharmaceutical compositions
containing such compounds, and to methods of treating cancer as well as
other disease states associated with unwanted angiogenesis and/or
cellular proliferation, such as diabetic retinopathy, neovascular
glaucoma, rheumatoid arthritis, and psoriasis, by administering effective
amounts of such compounds.
