There is provided DNA sequences isolated from Myxococcus xanthus partially
encoding a functional portion of a polypeptide component required for the synthesis
of antibiotic TA. Also provided are purified, isolated and cloned DNA sequences
encoding a polypeptide component required for postmodification of antibiotic TA
and encoding a gene product involved in the regulation of the biosynthesis of antibiotic
TA. A purified, isolated and cloned DNA sequence having a DNA sequence (seq. ID
No:2 and 20) encoding a polypeptide component required for encoding the TA gene
cluster and any mutations thereof is provided. Also provided are methods of using
the TA genes for combinatorial genetics and of using the TA genes encoding for
synthesis and modification or regulation of antibiotic TA.
