Biological samples of mammary fluid or components thereof are obtained
using a breast pump device coupled with a solid phase sample collection medium,
alternatively facilitated by administering oxytocin to the subject. The breast
pump device stimulates expression of mammary fluid and provides for collection
of diagnostic samples to evaluate breast disease, including cancer. The biological
sample may include whole cells or cellular components, purified or bulk proteins,
glycoproteins, peptides, nucleotides or other desired constituents comprising a
breast disease marker. Methods, kits and adapter devices relating to the breast
pump device are also provided. Yet additional methods, devices, accessories, and
materials are provided for laboratory handling and processing of breast fluid samples
and for related diagnostic methods.
