P/CAF interacts with and acetylates E2F, this acetylation affecting ability
of E2F to stimulate transcription. Interaction between P/CAF and E2F and acetylation
of E2F by P/CAF are modulated, affecting ability of E2F to stimulate transcription,
induction of S-phase in cells, oncogenicity of cells, and induction of apoptosis
in cells. Agents are obtained for treatment of disorders of cell growth.
