A method of preventing or treating pain or inflammation in a subject is
provided by administering to the subject a Cox-2 inhibitor and a
polyunsaturated fatty acid, or a prodrug thereof, wherein the amount of a
Cox-2 inhibitor and polyunsaturated fatty acid or a pharmaceutically
acceptable salt or prodrug thereof together constitute a pain or
inflammation suppressing treatment or prevention effective amount.
Glucosamine and/or chondroitin can optionally be present. Therapeutic
compositions that contain the combination of Cox-2 inhibitor and
polyunsaturated fatty acid and, optionally, the glucosamine and/or
chondroitin, are disclosed, as are pharmaceutical compositions.
